产品名称
ACSL3 Rabbit Polyclonal Antibody
基因名称
ACSL3 ACS3 FACL3 LACS3
蛋白名称
Long-chain-fatty-acid--CoA ligase 3 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 3) (LACS 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O95573
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95573/entry
Mouse Swissprot No.
Q9CZW4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CZW4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63151
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
ACSL3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Epithelium,Liver,Lung,Pancreas,Placenta,
细胞定位
Mitochondrion outer membrane ; Single-pass type III membrane protein . Peroxisome membrane ; Single-pass type III membrane protein . Microsome membrane ; Single-pass type III membrane protein . Endoplasmic reticulum membrane ; Single-pass type III membrane protein .
信号通路
Fatty acid metabolism;PPAR;Adipocytokine;
功能
catalytic activity:ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.,cofactor:Magnesium.,function:Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates.,similarity:Belongs to the ATP-dependent AMP-binding enzyme family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
