RM4741

MAP1LC3A (9M4) Rabbit Monoclonal Antibody

ATG8E; Autophagy-related ubiquitin-like modifier LC3 A; LC3; LC3A; MAP1 light chain 3 like protein 1; MAP1A/1B light chain 3A;

Affinity-chromatography

常规抗体

MAP1LC3A

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

84557

Q9H492

A synthetic peptide of human MAP1LC3A

WB: 1:2000 IHC: 1:20 ICC/IF: 1:20-1:100 FC: 1:20-1:100 IP: 1:20

16kDa

14kDa

Rabbit IgG

MAP1LC3A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid- anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).

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