产品名称
Gli1 (17P5) Rabbit Monoclonal Antibody
别名
Zinc finger protein GLI1; Glioma-associated oncogene; Oncogene GLI; Zfp5; GLI family zinc finger 1;GLI;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P08151
注意事项
Gli1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761)
细胞定位
Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU (PubMed:10806483). Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483). Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745). Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441)
功能
Acts as a transcriptional activator (PubMed:
19706761, PubMed:
10806483, PubMed:
19878745, PubMed:
24076122, PubMed:
24311597, PubMed:
24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:
2105456, PubMed:
8378770, PubMed:
24217340). Regulates the transcription of specific genes during normal development (PubMed:
19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:
19706761, PubMed:
28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:
11238441, PubMed:
28973407).
