产品名称
CD68 (6P4) Rabbit Monoclonal Antibody
别名
CD68 antigen; CD68 molecule; Gp110; LAMP4; Macrophage antigen CD68 (microsialin); Macrosialin; SCARD1; Scavenger receptor class D member 1;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P34810
注意事项
CD68 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
细胞定位
[Isoform Short]: Cell membrane; Single-pass type I membrane protein
功能
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
