产品名称
HNF-4-alpha (2F6) Rabbit Monoclonal Antibody
别名
NR2A1; HNF4A; Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; Transcription factor 14; TCF-14; Transcription factor HNF-4; HNF4; TCF14; Nuclear receptor subfamily 2 group A member 1;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P41235
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:50
注意事项
HNF-4-alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
功能
Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:
30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK- ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:
30530698).