产品名称
ADIPOR1 (12R16) Rabbit Monoclonal Antibody
别名
Adiponectin receptor protein 1; Progestin and adipoQ receptor family member I ; CGI-45; PAQR1; ADIPOR1;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q96A54
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:50
注意事项
ADIPOR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337). Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337). Weakly expressed in colon, thymus and small intestine (PubMed:12802337)
细胞定位
Cell membrane; Multi-pass membrane protein Note=Localized to the cell membrane and intracellular organelles
功能
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:
25855295, PubMed:
12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).
