产品名称
JAG1 (10E17) Rabbit Monoclonal Antibody
别名
JAG1; AGS; AHD; Alagille syndrome; CD339 antigen; HJ1; Jagged1; JAGL1; Jagged; Jagged 1; Protein jagged-1; AWS; CD339; Soluble protein jagged;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P78504
稀释度
WB 1:500~1:2000 IHC 1:50~1:200
注意事项
JAG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells
细胞定位
Membrane; Single-pass type I membrane protein.
功能
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:
18660822, PubMed:
20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:
9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
