产品名称
MTCO2 (4Z12) Rabbit Monoclonal Antibody
别名
Co2,Cytochrome c oxidase polypeptide II,Cytochrome c oxidase subunit 2,COII,COX2, COXII,MTCO2,MT-CO2
纯度
Affinity-chromatography
蛋白名称
Cytochrome c oxidase subunit 2 (Cytochrome c oxidase polypeptide II)
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P00403
免疫原
A synthetic peptide of human MTCO2
稀释度
WB: 1:1000-1:5000 IHC: 1:20-1:100 ICC/IF: 1:20 FC: 1:20 IP: 1:20
注意事项
MTCO2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Mitochondrion inner membrane; Multi-pass membrane protein
功能
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
