RM4689

Mast Cell Tryptase (7Q2) Rabbit Monoclonal Antibody

TPS1; TPS2; TPSAB1; TPSB1; MCP 7 ; Mast cell protease 7; Tryptase alpha 1;

Affinity-chromatography

常规抗体

TPSAB1

TPS1, TPS2, TPSB1

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

7177

Q15661

WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50

31kDa

Rabbit IgG

Mast Cell Tryptase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level)

Secreted. Note=Released from the secretory granules upon mast cell activation.

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).

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