RM4688

DKK1 (7G7) Rabbit Monoclonal Antibody

SK; DKK-1; Dickkopf-related protein 1; Dickkopf-1; hDkk-1; Dickkopf homolog 1;

Affinity-chromatography

常规抗体

DKK1

WB

Human,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

22943

O94907

WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:50

29kDa

Rabbit IgG

DKK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Placenta.

Secreted.

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).

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