产品名称
MUC1 (8S2) Rabbit Monoclonal Antibody
别名
MUC1; CA15-3; CD227; DF3 antigen; Episialin; Epithelial membrane antigen; H23 antigen; H23AG; Krebs von den Lungen-6; MAM6; MUC1/ZD; MUC-1/SEC; Mucin-1; Pem; KL-6; MUC-1/X; Tumor-associated mucin;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P15941
免疫原
A synthetic peptide of human MUC1
稀释度
WB: 1:1000 IHC: 1:20-1:500 ICC/IF: 1:100 FC: 1:20 IP: 1:20
注意事项
MUC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform Y is expressed in tumor cells only
细胞定位
Apical cell membrane; Single-pass type I membrane protein. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells After endocytosis, internalized and recycled to the cell membrane Located to microvilli and to the tips of long filopodial protusions [Isoform Y]: Secreted. [Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus
功能
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
