产品名称
Myosin Light Chain 2 (8D15) Rabbit Monoclonal Antibody
别名
MYL2; MLC2; Myosin light chain 2; MLC-2; RLC of myosin; CMH10; MLC-2v;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P10916
免疫原
A synthetic peptide of human Myosin Light Chain 2
稀释度
WB: 1:1000-1:5000 IHC: 1:200-1:500
注意事项
Myosin Light Chain 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cytoplasm, myofibril, sarcomere, A band {ECO:0000250|UniProtKB:P08733}
功能
Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).
