产品名称
Smac/Diablo (6O19) Rabbit Monoclonal Antibody
别名
SMAC; DFNA64; DIABLO; SMAC3;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9NR28
免疫原
A synthetic peptide of human Smac/Diablo
稀释度
WB: 1:1000 IHC: 1:20-1:100 ICC/IF: 1:100 FC: 1:20 IP: 1:20-1:50
注意事项
Smac/Diablo Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed
细胞定位
Mitochondrion. Note=Released into the cytosol when cells undergo apoptosis
功能
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
