RM4657

HMBS (7B17) Rabbit Monoclonal Antibody

UPS; PBGD; PORC; PBG-D; HMBS; Hydroxymethylbilane synthase;

Affinity-chromatography

常规抗体

HMBS

PBGD, UPS

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

3145

P08397

A synthetic peptide of human HMBS/PBGD

WB: 1:1000

39kDa

39kDa

Rabbit IgG

HMBS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

[Isoform 1]: Is ubiquitously expressed.

Cytoplasm.

As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen (PubMed:18936296, PubMed:19138865, PubMed:23815679). Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact (PubMed:18936296).

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