RM4652

hnRNP C1/C2 (13H15) Rabbit Monoclonal Antibody

HNRNPC; HNRPC; Heterogeneous nuclear ribonucleoproteins C1/C2; ROC; hnRNP C1 / hnRNP C2; hnRNP-C1/C2;

Affinity-chromatography

常规抗体

HNRNPC

HNRPC

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

3183

P07910

WB 1:5000~1:20000 IHC 1:100~1:200 ICC/IF 1:100~1:200 IP 1:50 FC 1:50

34kDa

Rabbit IgG

hnRNP C1/C2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus. Note=Component of ribonucleosomes.

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

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