产品名称
P Glycoprotein (6J13) Rabbit Monoclonal Antibody
别名
CD243; MDR1; MDR3; Multidrug resistance protein 1; P-glycoprotein 1; PGY1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P08183
免疫原
Recombinant protein of human P Glycoprotein
稀释度
WB: 1:1000-1:2000 IHC: 1:50-1:200
注意事项
P Glycoprotein Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in liver, kidney, small intestine and brain
细胞定位
Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Apical cell membrane
功能
Translocates drugs and phospholipids across the membrane (PubMed:
8898203, PubMed:
2897240, PubMed:
9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:
8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:
2897240, PubMed:
9038218).
