产品名称
A4GAT Rabbit Polyclonal Antibody
基因名称
A4GALT A14GALT A4GALT1
蛋白名称
Lactosylceramide 4-alpha-galactosyltransferase (EC 2.4.1.228) (Alpha-1,4-N-acetylglucosaminyltransferase) (Alpha-1,4-galactosyltransferase) (Alpha4Gal-T1) (CD77 synthase) (Globotriaosylceramide synthase) (Gb3 synthase) (P1/Pk synthase) (UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NPC4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NPC4/entry
Mouse Swissprot No.
Q67BJ4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q67BJ4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9JI93
免疫原
Synthesized peptide derived from part region of human protein
特异性
A4GAT Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
alpha 1,4-galactosyltransferase(A4GALT) Homo sapiens The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. This protein, a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015],
组织表达
Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein .
信号通路
Glycosphingolipid biosynthesis;
功能
catalytic activity:UDP-galactose + beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide.,domain:The conserved DXD motif is involved in enzyme activity.,function:Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.,online information:GlycoGene database,online information:Lactosylceramide 4-alpha-galactosyltransferase,pathway:Protein modification; protein glycosylation.,polymorphism:Different combinations or absence of the P blood group system antigens define 5 different phenotypes: P1, P2, P1(k), P2(k), and p. Genetic variation in A4GALT determines the p phenotype, which is rare and does not express any antigens. It is also known as null phenotype; p individuals have antibodies against P, P1 and Pk antigens in their sera. These antibodies are clinically important because they can cause severe transfusion reactions and miscarriage.,similarity:Belongs to the glycosyltransferase 32 family.,tissue specificity:Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
