产品名称
Catenin alpha 1 (8X15) Rabbit Monoclonal Antibody
别名
102 kDa cadherin-associated protein; Alpha E-catenin; CATNA1; CTN1; Cadherin-associated protein; catenin alpha-1; Catenin alpha 1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P35221
免疫原
A synthetic peptide of human alpha 1 Catenin
稀释度
WB: 1:5000 IHC: 1:20 ICC/IF: 1:50 FC: 1:20 IP: 1:20
注意事项
Catenin alpha 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed ubiquitously in normal tissues.
细胞定位
[Isoform 1]: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries
功能
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1- dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation.
