RM4612

Phospho-SHP2 (Y542) (7K17) Rabbit Monoclonal Antibody

BPTP3; CFC; MGC14433; NS1; PTN11; PTP-1D; PTP-2C; PTP2C; PTPN11; SH-PTP2; SH-PTP3; SHP-2; Shp2; SHPTP2;

Affinity-chromatography

常规抗体

PTPN11

PTP2C, SHPTP2

WB

Human,Mouse

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

5781

Q06124

WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50

68kDa

Rabbit IgG

Phospho-SHP2 (Y542) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Cytoplasm. Nucleus

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity).

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