RM4594

Fibronectin (5H16) Rabbit Monoclonal Antibody

Anastellin; CIG; Cold-insoluble globulin; ED-B; Fibronectin; fibronectin 1; FINC; FN1; FNZ; GFND; GFND2; LETS; migration-stimulating factor; MSF;

Affinity-chromatography

常规抗体

FN1

FN

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

2335

P02751

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

272kDa

Rabbit IgG

Fibronectin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in the inner limiting membrane and around blood vessels in the retina (at protein level) (PubMed:29777959) Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine (PubMed:17614963).

Secreted, extracellular space, extracellular matrix

Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).

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