RM4576

CD11a (18K4) Rabbit Monoclonal Antibody

CD11A; LFA-1; LFA1A; p180; ITGAL;

Affinity-chromatography

常规抗体

ITGAL

CD11A

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

3683

P20701

A synthetic peptide of human CD11a

WB: 1:1000 IHC: 1:200 ICC/IF: 1:20 FC: 1:20 IP: 1:20

150kDa

129kDa

Rabbit IgG

CD11a Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Leukocytes.

Cell membrane; Single-pass type I membrane protein

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).

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