RM4575

GRK2 (12K5) Rabbit Monoclonal Antibody

GRK2; BARK1; FLJ16718; BETA-ARK1; ADRBK1;

Affinity-chromatography

常规抗体

GRK2

ADRBK1, BARK, BARK1

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

156

P25098

A synthetic peptide of human GRK2

WB: 1:1000 IP: 1:20

80kDa

80kDa

Rabbit IgG

GRK2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in peripheral blood leukocytes.

Cytoplasm {ECO:0000250|UniProtKB:P21146}. Cell membrane {ECO:0000250|UniProtKB:P21146}

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925). Desensitizes LPAR1 and LPAR2 in a phosphorylation- independent manner (PubMed:19306925). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927).

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