产品名称
Tuberin (14C7) Rabbit Monoclonal Antibody
别名
TSC2; Tuberous sclerosis 2 homolog protein; Tuberous sclerosis 2 protein; Tuberin;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P49815
免疫原
A synthetic peptide of human Tuberin
稀释度
WB: 1:5000 IHC: 1:20 ICC/IF: 1:20 FC: 1:200-1:1000 IP: 1:20
注意事项
Tuberin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta
细胞定位
Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes
功能
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:
12271141, PubMed:
28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:
15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).
