产品名称
ICAM5 Rabbit Polyclonal Antibody
蛋白名称
Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UMF0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UMF0/entry
Mouse Swissprot No.
Q60625
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60625
免疫原
Synthesized peptide derived from part region of human protein
特异性
ICAM5 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008],
组织表达
Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.
细胞定位
Membrane; Single-pass type I membrane protein.
功能
function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 9 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
