RM4550

BDNF (10T8) Rabbit Monoclonal Antibody

BDNF;MGC34632;Abrineurin; ANON2; Brain Derived Neurotrophic Factor; Neurotrophin;BULN2;

Affinity-chromatography

常规抗体

BDNF {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:1033}

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

627

P23560

WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

28kDa

Rabbit IgG

BDNF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Detected in blood plasma and in saliva (at protein level) (PubMed:11152678, PubMed:19467646). Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta

Secreted

Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

现货