Cn|En

现货抗体产品库

PIM1 (3I7) Rabbit Monoclonal Antibody

产品详情 相关文献 产品问答 相关产品

产品基本信息

产品货号
RM4529
产品名称
PIM1 (3I7) Rabbit Monoclonal Antibody
别名
Oncogene PIM1; PIM; pim-1 kinase 44 kDa isoform; pim-1 oncogene; pim-1 oncogene (proviral integration site 1); PIM1;
纯度
Affinity-chromatography
类别
常规抗体
基因名称
PIM1
推荐应用
WB
反应种属
Human,Mouse
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Gene ID
5292
Human Swissprot No.
P11309
免疫原
A synthetic peptide of human PIM1
稀释度
WB: 1:2000-1:10000 IHC: 1:20-1:50 ICC/IF: 1:20-1:100 FC: 1:20
参考分子量
34kDa
预测分子量
45kDa
同种型
Rabbit IgG
注意事项
PIM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.
细胞定位
[Isoform 1]: Cytoplasm. Nucleus.
功能
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl- X(L)/BCL2L1. Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post- translational levels. Phosphorylation of CDKN1B, induces 14-3-3 proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12- CXCR4 signaling axis. Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells (PubMed:18056989). Promotes brown adipocyte differentiation (By similarity).
期货
现货

Western blot analysis of PIM1 expression in Jurkat cell lysate.

相关文献

产品问答

相关产品

免责声明| 法律支持| 联系方式

市场:027-65023363   行政/人事:027-62439686   邮箱:marketing@brainvta.com  

销售总监:张经理  18995532642  华东区:陈经理 18013970337   华南区:王经理 13100653525   华中/西区:杨经理 18186518905   华北区:张经理 18893721749

地址:中国武汉东湖高新区光谷七路128号中科开物产业园1号楼

Copyright © 武汉枢密脑科学技术有限公司. All RIGHTS RESERVED.
鄂ICP备2021009124号 DIGITAL BY VTHINK