产品名称
S22AG Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/85413
Human Swissprot No.
Q86VW1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86VW1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/70840
Mouse Swissprot No.
Q497L8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q497L8
免疫原
Synthesized peptide derived from human S22AG AA range: 49-99
特异性
This antibody detects endogenous levels of S22AG at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011],
组织表达
Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase.
细胞定位
Membrane ; Multi-pass membrane protein . Cell membrane . Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis.
功能
function:High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.,similarity:Belongs to the major facilitator superfamily. Organic cation transporter family.,subcellular location:Detected in the plasma mebrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymus.,tissue specificity:Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymus (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
