产品名称
p21 (8X12) Rabbit Monoclonal Antibody
别名
CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1
纯度
Affinity-chromatography
蛋白名称
CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WA
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P38936
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200
注意事项
p21 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in all adult tissues, with 5-fold lower levels observed in the brain
功能
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin- dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D- CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:
11595739). Plays an important role in controlling cell cycle progression and DNA damage- induced G2 arrest (PubMed:
9106657).
