RM4511

HIF-1 beta (14M15) Rabbit Monoclonal Antibody

ARNT;HIF-1beta;HIF1B;HIF1BETA;TANGO;bHLHe2;

Affinity-chromatography

常规抗体

ARNT

BHLHE2

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

405

P27540

Recombinant protein of human HIF1 beta

WB: 1:1000 IHC: 1:50 FC: 1:50

87kDa

87kDa

Rabbit IgG

HIF-1 beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus.

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).

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