产品名称
Dnmt3a (12V15) Rabbit Monoclonal Antibody
别名
DNMT3A2; M.HsaIIIA; Dnmt3a; MCMT; DNA methyltransferase 3a;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9Y6K1
免疫原
A synthetic peptide of human Dnmt3a
注意事项
Dnmt3a Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung
细胞定位
Nucleus. Chromosome Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin {ECO:0000250|UniProtKB:O88508}
功能
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:
12138111, PubMed:
16357870, PubMed:
30478443). DNA methylation is coordinated with methylation of histones (PubMed:
12138111, PubMed:
16357870, PubMed:
30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:
12138111, PubMed:
16357870, PubMed:
30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity).
