产品名称
MAP1LC3A (5D4) Rabbit Monoclonal Antibody
别名
MAP1LC3;LC3;LC3A;MAP1ALC3;MAP1BLC3 ;MAP1LC3A;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9H492
免疫原
A synthetic peptide of human MAP1LC3A
稀释度
WB: 1:5000 IHC: 1:20 ICC/IF: 1:20 IP: 1:20
注意事项
MAP1LC3A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes
细胞定位
Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid- anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes
功能
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:
20713600, PubMed:
24290141). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:
20713600). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:
31006538, PubMed:
31006537).
