RM4499

ASH2L (10A13) Rabbit Monoclonal Antibody

ASH 2; ASH2; ASH2 LIKE; ASH2 like protein; ASH2-like protein; Ash2l; ASH2L1; ASH2L2; Bre 2; Bre2;

Affinity-chromatography

常规抗体

ASH2L

ASH2L1

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

9070

Q9UBL3

A synthetic peptide of human ASH2L

WB: 1:2000-1:10000 IHC: 1:20 ICC/IF: 1:50 FC: 1:200

80kDa

69kDa

Rabbit IgG

ASH2L Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes.

Nucleus.

Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).

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