产品名称
Cytokeratin 17 (9F13) Rabbit Monoclonal Antibody
别名
39.1; CK-17; Cytokeratin-17; K17; K1C17; keratin 17; Keratin, type I cytoskeletal 17; Keratin-17; KRT17; PC; PC2; PCHC1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q04695
免疫原
A synthetic peptide of human Cytokeratin 17
稀释度
WB: 1:2000 IHC: 1:20 ICC/IF: 1:20 IP: 1:20
注意事项
Cytokeratin 17 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level)
细胞定位
Cytoplasm {ECO:0000250|UniProtKB:Q9QWL7}.
功能
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
