产品名称
HP1 alpha (18P10) Rabbit Monoclonal Antibody
别名
CBX5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P45973
免疫原
A synthetic peptide of human HP1 alpha
稀释度
WB: 1:2000-1:10000 IHC: 1:50 ICC/IF: 1:50 FC: 1:20 IP: 1:20
注意事项
HP1 alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Nucleus. Chromosome Chromosome, centromere. Note=Colocalizes with HNRNPU in the nucleus (PubMed:19617346). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase
功能
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
