产品名称
HAP1 Rabbit Polyclonal Antibody
蛋白名称
Huntingtin-associated protein 1 (HAP-1) (Neuroan 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P54257
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P54257/entry
Mouse Swissprot No.
O35668
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35668
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P54256
免疫原
Synthesized peptide derived from part region of human protein
特异性
HAP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
组织表达
Predominantly expressed in brain. Selectively expressed in neurons.
细胞定位
Cytoplasm . Cell projection, axon . Cell junction, synapse, presynapse . Cytoplasm, cytoskeleton . Cell projection, dendritic spine . Cell projection, dendrite . Lysosome . Endoplasmic reticulum . Mitochondrion . Nucleus . Cytoplasmic vesicle, autophagosome . Early endosome . Cell projection, growth cone . Cell projection, neuron projection . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . Localizes to large nonmembrane-bound cytoplasmic bodies found in various types of neurons, called stigmoid bodies (STBs). Localization to neuronal processes and neurite tips is decreased by YWHAZ. In the nucleus localizes to nuclear rods. .
信号通路
Huntington's disease;
功能
alternative products:Additional isoforms seem to exist,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat.,similarity:Contains 1 HAP1 N-terminal domain.,tissue specificity:Predominantly expressed in brain. Selectively expressed in neurons.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
