RM4467

Caspase-2 (13Q18) Rabbit Monoclonal Antibody

Caspase-2; Caspase 2; Caspase2; CASP-2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1; CASP2; ICH1; NEDD2

Affinity-chromatography

常规抗体

CASP2

ICH1, NEDD2

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

835

P42575

Recombinant protein of human Caspase-2

WB: 1:1000 IHC: 1:200 ICC/IF: 1:200-1:500 FC: 1:200-1:500

48kDa

51kDa

Rabbit IgG

Caspase-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321).

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