产品名称
HOME1 Rabbit Polyclonal Antibody
蛋白名称
Homer protein homolog 1 (Homer-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q86YM7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86YM7/entry
Mouse Swissprot No.
Q9Z2Y3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z2Y3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9Z214
免疫原
Synthesized peptide derived from part region of human protein
特异性
HOME1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008],
组织表达
Brain,Frontal cortex,Pancreas,Stomach mucosa,Synovial cell,
细胞定位
Cytoplasm . Cell junction, synapse, postsynaptic density . Cell junction, synapse . Cell projection, dendritic spine . Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. .
功能
domain:The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.,function:Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.,similarity:Belongs to the Homer family.,similarity:Contains 1 WH1 domain.,subcellular location:Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum.,subunit:Interacts with IFT57 (By similarity). Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
