产品名称
PUMA (16H9) Rabbit Monoclonal Antibody
别名
BBC3; bcl2 binding component 3; jfy1; puma; p53 up-regulated modulator of apoptosis; PUMA alpha;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9BXH1
免疫原
A synthetic peptide of human PUMA
稀释度
WB: 1:1000 IHC: 1:20-1:100 ICC/IF: 1:50-1:100 FC: 1:20
注意事项
PUMA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitously expressed.
细胞定位
Mitochondrion Note=Localized to the mitochondria in order to induce cytochrome c release
功能
Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis (PubMed:
11463391). Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:
23340338).
