产品名称
SOX18 (7L17) Rabbit Monoclonal Antibody
别名
HLTS; Sox18 ; SRY box 18; Transcription factor SOX 18;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P35713
稀释度
WB 1:500~1:2000 IHC 1:50~1:200
注意事项
SOX18 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Detected in heart, lung, placenta, skeletal muscle, liver, kidney, spleen, prostate, ovary, msosmall intestine and colon
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
功能
Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development.
