RM4417

DUSP6 (9T14) Rabbit Monoclonal Antibody

HH19; MKP3; PYST1; DUSP6; DUSP6a; Dual specificity phosphatase 6;

Affinity-chromatography

常规抗体

DUSP6

MKP3, PYST1

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

1848

Q16828

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:50

42kDa

Rabbit IgG

DUSP6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in keratinocytes (at protein level).

Cytoplasm.

Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977).

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