产品名称
TGIF2 Rabbit Polyclonal Antibody
蛋白名称
Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9GZN2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9GZN2/entry
Mouse Swissprot No.
Q8C0Y1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C0Y1
免疫原
Synthesized peptide derived from part region of human protein
特异性
TGIF2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010],
组织表达
Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.
细胞定位
Nucleus. Excluded from nucleoli.
功能
function:Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.,miscellaneous:TGIF2 is amplified and overexpressed in several ovarian cancer cell lines.,PTM:The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.,similarity:Belongs to the TALE/TGIF homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subcellular location:Excluded from nucleoli.,subunit:Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1.,tissue specificity:Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
