产品名称
EpCAM (17E13) Rabbit Monoclonal Antibody
别名
ESA; KSA; M4S1; MK1; DIAR5; EGP2;EGP40; KS1/4; MIC18; TROP1; TACSTD1; EPCAM;
纯度
Affinity-chromatography
蛋白名称
GA733-2, M1S2, M4S1, MIC18, TACSTD1, TRO
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P16422
注意事项
EpCAM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC) Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.
细胞定位
Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction
功能
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
