产品名称
Bak (16T6) Rabbit Monoclonal Antibody
别名
BAK1;BAK;BAK-LIKE;BCL2L7;CDN1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q16611
免疫原
A synthetic peptide of human Bak
稀释度
WB: 1:2000-1:10000 IHC: 1:100-1:200 ICC/IF: 1:50 FC: 1:20 IP: 1:20
注意事项
Bak Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle
细胞定位
Mitochondrion outer membrane; Single-pass membrane protein
功能
Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.
