产品名称
ABCG1 (9S10) Rabbit Monoclonal Antibody
别名
ATP-binding cassette transporter 8; White protein homolog; ABC8; WHT1;ABCG1; ABC transporter 8; WHITE1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P45844
免疫原
A synthetic peptide of human ABCG1
稀释度
WB: 1:2000 ICC/IF: 1:20
注意事项
ABCG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.
细胞定位
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes
功能
Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta- hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:
17408620, PubMed:
24576892). The lipid efflux is ALB-dependent (PubMed:
16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta- hydroxycholesterol (PubMed:
17408620).
