产品名称
SHP1 (9X10) Rabbit Monoclonal Antibody
别名
70Z-SHP; EC 3.1.3.48; HCP; HCPH; PTN6; PTP-1C; PTP1C; PTPN6; SH-PTP1; SHP1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P29350
免疫原
A synthetic peptide of human SHP1
注意事项
SHP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells
细胞定位
Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity) Shuttles between the cytoplasm and nucleus via its association with PDPK1.
功能
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
