产品名称
GLUT1 (17B12) Rabbit Monoclonal Antibody
别名
DYT17; DYT18; Glucose transporter type 1, erythrocyte/brain; GLUT; GLUT-1; GLUT1; GTR1; HepG2 glucose transporter;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P11166
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:50
注意事项
GLUT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues
细胞定位
Cell membrane; Multi-pass membrane protein. Melanosome. Photoreceptor inner segment {ECO:0000250|UniProtKB:P17809}. Note=Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:25982116, PubMed:24847886). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065)
功能
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:
18245775, PubMed:
19449892, PubMed:
25982116, PubMed:
27078104, PubMed:
10227690). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:
18245775, PubMed:
19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:
10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).
