产品名称
p16 INK (16J3) Rabbit Monoclonal Antibody
别名
CDKN2A; CDKN2; MTS1; isoforms 1/2/3; Cyclin-dependent kinase 4 inhibitor A; CDK4I; P16INK4; p16INK4a; Multiple tumor suppressor 1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P42771
免疫原
A synthetic peptide of human CDKN2A/p16INK4a
稀释度
WB: 1:1000 IHC: 1:100 ICC/IF: 1:200 FC: 1:200-1:500 IP: 1:20
注意事项
p16 INK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific
功能
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
