RM4364

PI 3 Kinase p85 alpha (17X10) Rabbit Monoclonal Antibody

GRB1; P85A; PI3-kinase p85-alpha; PI3K; PI3K p85-alpha; ptdIns-3-kinase p85-alpha;

Affinity-chromatography

常规抗体

PIK3R1

GRB1

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

5295

P27986

A synthetic peptide of human PI 3 Kinase p85 alpha

WB: 1:1000

84kDa

84kDa

Rabbit IgG

PI 3 Kinase p85 alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level)

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).

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