产品名称
VPREB Rabbit Polyclonal Antibody
蛋白名称
Immunoglobulin iota chain (CD179 antigen-like family member A) (Protein VPreB1) (V(pre)B protein) (VpreB protein) (CD antigen CD179a)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P12018
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P12018/entry
免疫原
Synthesized peptide derived from part region of human protein
特异性
VPREB Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],
组织表达
Only expressed by pre-B-cells.
细胞定位
Endoplasmic reticulum .
功能
function:Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates ig gene rearrangements in the early steps of B-cell differentiation.,similarity:Belongs to the immunoglobulin superfamily.,subunit:Associates non-covalently with IGLL1.,tissue specificity:Only expressed by pre-B-cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
