产品名称
beta 2 Microglobulin (18W13) Rabbit Monoclonal Antibody
别名
B2MG; Beta 2 microglobin; Beta 2 microglobulin; Beta-2-microglobulin form pI 5.3; CDABP0092; Hdcma22p;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P61769
免疫原
A synthetic peptide of human beta 2 Microglobulin
稀释度
WB: 1:1000 ICC/IF: 1:50-1:200 FC: 1:20 IP: 1:20
注意事项
beta 2 Microglobulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Secreted. Cell surface. Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280). {ECO:0000269|PubMed:7554280, ECO:0000269|Ref.6}
功能
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:
25356553).
